Knowns and Unknowns of Assaying ADCC against HIV

Antibody-dependent cellular cytotoxicity (ADCC) and other Fc-mediated effector functions have been shown to play a role in protection against viral infections and may play a role in protection against HIV. A number of assays have been developed to measure ADCC activity, but it has been difficult to recapitulate the complexities of this process in vitro, challenging the reproducibility of the assays and complicating cross-assay comparisons.

The Global HIV Vaccine Enterprise organized a half-day workshop that brought together key experts in the field to discuss the knowns and unknowns of what we can learn from various ADCC assays. The meeting reviewed currently available assays, compared methodologies, explored how readouts from different assays can be correlated, and discussed which assays are sufficiently mature to be used to assess immune responses in clinical trials of HIV vaccine candidates. Outcomes of these discussions will be shared with the wider research community.

Date: 28 March, 2017

Location:
Steamboat Sheraton Resort
Steamboat Springs, CO

Deliverables:
A meeting report to present the meeting outcomes to a larger audience.

Meeting Co-chairs:
Nicole Frahm, Fred Hutchinson Cancer Research Center
George Lewis, University of Maryland
Christiane Moog, University of Strasbourg
Gabriella Scarlatti, Global HIV Vaccine Enterprise

If you have any questions about the meeting, please contact enterprise@iasociaty.org 

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