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Enterprise Published a Consensus Summary Document on Vaccine-induced Sero-reactivity

HIV vaccine-induced sero-reactivity: A challenge for trial participants, researchers, and physicians - Antibody-inducing vaccines are a major focus in the preventive HIV vaccine field.  Because the most common tests for HIV infection rely on detecting antibodies to HIV, they may also detect antibodies induced by a candidate HIV vaccine.  The detection of vaccine-induced antibodies to HIV by serological tests is most commonly referred to as vaccine-induced sero-reactivity (VISR).  VISR can be misinterpreted as a sign of HIV infection in a healthy study participant.  In a participant who has developed vaccine-induced antibodies, accurate diagnosis of HIV infection (or lack thereof) may require specialized tests and algorithms (differential testing) that are usually not available in community settings.  Read more.

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